UNLOCK THE BEST SCIENCE FOR TOMORROW
Through high-quality alliance and project management, we are delighted to offer integrated support to help accelerating our partner’s discovery efforts with optimized clinical results and confirmatory proof of concept.
- We welcome innovative target proposals from academic and other researchers anywhere in the world, in our key focus areas. This includes phenotypic as well as molecular target screening proposals and proposals for accessing fragment screening libraries. Our scientists will rapidly review proposals and consider whether we can assist in advancing your idea through to validation. If your concept proposal is selected, we will support you in developing your idea into a full proposal.
- We can supply high quality diversity screening sets for you to perform hit identification. Our early discovery and high throughput screening capabilities enable us to screen thousands of compounds to identify molecules with potential to inhibit or activate the target. You can opt to screen an entire set or select a subset depending on the throughput of your assay technology.
FLEXIBILITY AND RELIABILITY
- We offer flexible services and alliances based on our competitive capabilities spanning the pre-clinical discovery process. Services provided by us cover a range of drug discovery activities with great flexibility to respond to each client’s specific project needs. Running your study under our flexible engagement model gives you access to our remarkable sector expertise and an innovative multi-disciplinary technology platform to help sustain your research engine for a variety of discovery projects.
- Our discovery services are provided on a typical fee-for-service basis or through a variety of commercial structures including research fees, milestones and/or royalties. (contact us for further information)
COLLABORATIVE DRUG DISCOVERY SERVICES
- Providing expert advice to medical researchers who seek guidance in medicinal chemistry
- Structure-based design of small-molecule inhibitors targeting proteins of interest
- Construction of libraries of small molecules
- Structure-based virtual screening
- Cell-based chemical screening (MTT assay, in vitro phosphatase assay, in vitro lactate secretion assay, intracellular pH assay etc.)
- Validation of the interaction between compounds and target protein (Open SPR, downstream protein signal detection, Enzyme activity analysis)
- Molecular modification
- Hit-to-lead optimization to improve drug-like properties and secondary virtual screening
- Synthesis and identification of small molecules identified as bioactive
- Animal model studies
- Support for individual and center-based research grants
- State of the art analytical capabilities
TARGET SELECTION
- Define the unmet medical need (disease)
- Understand the molecular mechanism of the disease
- Identify a therapeutic target in that pathway
- Demonstrate that target is relevant to disease mechanism using genetics, animal models, lead compounds, antibodies,RNAi, etc.
COMPOUND SCREENING & SCONDARY ASSAYS
- Screen collection of compounds
- Compound from published literature
- Screen Natural Products
- Structure-based design
LEAD CANDIDATE CONFIRMATION
- Optimize to determine Proof-of-concept or Drug-like properties - basic pharmacokinetics, metabolism, off-target activities
- Preliminary Safety Assessment
- Preliminary Toxicity Assessment
- Pre-clinical Drug Candidate Confirmation